One of the most significant and complex health issues in our country is cancer. Coping with psychological syptoms of cancer such as stress, anxiety and depression is the most challenging blind spot for patients suffering from the cancer. The purpose of this study is to predict coping self-efficacy based on social support, personal growth and mindfulness in people with cancer. 120 participants were selected through available sampling method. For collecting data, social support questionnaire, Robitschek's personal growth initiative scale, the Freiburg mindfulness inventory and the coping self-efficacy scale have been used. For data analysis, multiple regression is used in an Enter method. The results show a positive and critical relationship between social support, personal growth and mindfulness with coping self-efficacy. Also, the results proves that social support, personal growth and mindfulness explains 60% of the variance of coping self-efficacy. In general, the findings of the present article have supported the role of social support, personal growth and mind-awareness in coping self-efficacy in cancer patients.