Personality traits of each person form his main psychological structure which helps to shape his life style. So, the purpose of this study was to determine therelation betweenpersonality traits with spiritual intelligence and quality of life in students . This descriptive study was correlational. All students of AllamehTabatabaie University took part in this study in 2009-2020. Among them, 200 students (100 girls and 100 boys) were selected through multistage cluster sampling based on Morgan formula. Spiritual Intelligence, SF36 & BFI were used for data collection. Data were analyzed using Pearson correlation coefficient and stepwise regression analysis by means of SPSS version 19 . According to the results, quality of life and spiritual intelligence had positive correlation with Extraversion, Openness to experience, Agreeableness and Conscientiousness and had negative correlations with Neuroticism. Among personality traits, Extraversion, Agreeableness and Neuroticism could explain 20 percent of the variance of spiritual intelligence. Also, Neuroticism and Conscientiousness could account for about 41 percent of the variance of quality of life. These results can indicate that spiritual intelligence is a separate character of personality. Moreover, there are relations between quality of life and personality traits. It shows that individualswithhigherquality of lifecan be moresuccessful and have more healthyinterpersonalcommunication with others to getotherconsent .