The most important issues of psychology is psychosomatic disease. This study aimed to compare spiritual intelligence and emotional expression in patients with irritable bowel syndrome, coronary heart disease and asthma. This research was a post-event descriptive study. The statistical population included patients with coronary heart disease, irritable bowel syndrome and asthma that attended Imam Khomeini hospital, Tehran. The participants consisted of 150 participants (86 women, 64 men) with irritable bowel syndrome (n=50), coronary heart disease (n=50) and asthma (n=50). They answered King and Emmons’ emotional expressiveness questionnaire and King’s spiritual intelligence questionnaire. The results showed a significant relationship between spiritual intelligence and emotional expressiveness subscales and a low level of spiritual intelligence and emotional expressiveness in all three groups of patients. Comparing the three groups showed that spiritual intelligence and emotional expression were low in all of them and coronary heart disease was the lowest in three group of patient.