fa تعیین تاثیر تمرینات ترکیبی بر سطح ابستاتین ، گرلین و مقاومت به انسولین در زنان دارای اضافه‌وزن ● International Health مقاله اصيل پژوهشي Orginal Article <strong>Background</strong>: The present quasi-experimental and field research was conducted to evaluate the effect of combined exercises on the levels of obestatin and ghrelin in overweight women.<br> <strong>Methods</strong>: The study subjects consisted of 34 overweight women with a Mean&plusmn;SD age of 30.29&plusmn;4.66 years, a Mean&plusmn;SD height of 165.11&plusmn;5.56 cm, a Mean&plusmn;SD weight of 74.64&plusmn;7.33 kg, a Mean&plusmn;SD body mass index of 27.35&plusmn;1.74 kg/m2, which were selected purposefully and randomly, and assigned to the experimental (n=17) and control (n=17) groups. At first, venous blood samples were taken from subjects after 12 h overnight fasting to measure the levels of ghrelin, obestatin, glucose, insulin, and insulin resistance. Then, the participants of the experimental group participated in a combined exercise program, including warming up, aerobic training, resistance training, and cooling down. All these variables were re-measured after 12 weeks and the obtained data were analyzed. The paired t test was used for intra-group comparison and independent t test was performed for inter-group comparison.<br> <strong>Results</strong>: The findings of this study showed that body weight, BMI, waist circumference, glucose level, and ghrelin-obestatin ratio were significantly different between the experimental and the control groups (P&le;0.05) after 8 weeks of combined exercise training, but differences in ghrelin, obestatin, insulin levels, and insulin resistance were not significant between the experimental and control groups (P&le;0.05).<br> <strong>Conclusion</strong>: The combined exercise training, therefore, seems to be a suitable method for weight loss, body composition, waist circumference, glucose level, and ghrelin-obestatin ratio. Circuit-based exercise, Overweight, Ghrelin, Obestatin, Insulin resistance 287 294 http://jrh.gmu.ac.ir/browse.php?a_code=A-10-552-3&slc_lang=fa&sid=1 Zahra Yosefi Chermahini z66.usefi@gmail.com 1249482739 100319475328460018858 No Department of Physical Education and Sport Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran. دانشگاه آزاد خوراسگان Farzaneh Taghian فرزانه تقیان f_taghian@yahoo.com 1285862465 100319475328460018859 Yes Department of Physical Education and Sport Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran. دانشگاه آزاد خوراسگان Mehdi Hedayati مهدی هدایتی hedayati47@yahoo.com 4621665731 100319475328460018860 No Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences,Shahid Beheshti University of Medical Sciences, Tehran, Iran. دانشگاه شهید بهشتی