en The effect of aerobic training with supplementation of vitamins C and E on some inflammatory and cardiovascular risk factors of overweight men ● International Health مقاله اصيل پژوهشي Orginal Article <strong>Background</strong>: The purpose of this study was to investigate the effectiveness of aerobic training with supplementation of vitamins C and E on some inflammatory markers and cardiovascular risk factors in overweight men.&nbsp;<br> <strong>Methods</strong>: In this semi-experimental study, 30 overweight men were randomly assigned into three groups (n=10, AT+Sup, AT+Placebo, and control). The exercise program consisted of three sessions per week at the intensity of 60-75% of maximal heart rate for six weeks. The supplement group received 300 mg of vitamin E daily and 400 mg vitamin C tablet and the placebo group received one gelatin capsule daily during this period. Before and after six weeks of intervention, were measured interleukin-6 (IL-6), -reactive protein (CRP), Triglyceride (TG), Low-Density Lipoprotein (LDL), High-Density Lipoprotein (HDL), and insulin resistance index. Data were analyzed by t-test, one-way ANOVA, and Tukey post hoc test at a significance level of P<0.05.<br> <strong>Result</strong>: The results showed that aerobic training significantly reduced the body fat percentage, TG, and LDL in both supplement and placebo groups(P<0.05). However, this reduction was observed in IL-6 and CRP only in the supplement group (P<0.05). On the other hand, the results showed that exercise and supplementation did not change the insulin resistance of subjects. The results of one-way ANOVA showed that there was a significant difference between the three groups in fat percentage, IL-6, CRP, TG, and LDL (P<0.05).<br> <strong>Conclusion</strong>: According to the results of this research, probably six weeks of aerobic training plus supplementation with vitamin E and C may help to reduce inflammatory symptoms, body fat percentage, and some cardiovascular risk factors. Exercise, Interleukin-6, C-reactive protein, Vitamin E, Ascorbic acid 53 60 http://jrh.gmu.ac.ir/browse.php?a_code=A-10-579-5&slc_lang=en&sid=1 Bahram Abedi - - abedi@iaumahallat.ac.ir 1 100319475328460019661 No Department of Physical Education, Faculty of Humanities, Mahallat Branch, Islamic Azad University, Mahallat, Iran. - Ali Reza Elmieh - - elmieh@iaurasht.ac.ir 2 100319475328460019662 Yes Department of Physical Education, Faculty of Humanities, Rasht Branch, Islamic Azad University. Rasht, Iran. - Seyed Benyamin Emam - - benyaminemam@gmail.com 3 100319475328460019663 No Department of Physical Education, Faculty of Humanities, North Tehran Branch, Islamic Azad University, Tehran, Iran. - Hooman Khanbabakhani - - benyaminemam@gmail.com 4 100319475328460019664 No Department of Physical Education, Faculty of Humanities, Rasht Branch, Islamic Azad University. Rasht, Iran. -