en ● International Health مقاله اصيل پژوهشي Orginal Article <strong>Background</strong>: Mother-child interaction and spiritual well-being can influence child behavioral disorders by affecting the mother&rsquo;s mental health. The present study was done to investigate the relationship between mother-child interaction and spiritual well-being and child behavioral disorders with the mediation of mental health in mothers of children with hearing impairment.<br> <strong>Methods</strong>: The descriptive correlational study used a path analysis. The statistical population included 1580 mothers of children with hearing impairment in Tehran in 2019. The sample size was determined using Morgan&rsquo;s sample size table. The samples were selected based on stratified random sampling. To collect the required data, 310 questionnaires based on the research variables were provided to the participants and a total of 284 questionnaires were analyzed following the elimination of incomplete questionnaires. The research instruments included the Behavior Disorders Questionnaire, the Child-Parent Interaction Questionnaire, the Spiritual Well-being Questionnaire, and the Mental Health Questionnaire. The proposed model was evaluated using path analysis by AMOS v. 24 software.<br> <strong>Results</strong>: The results showed that there was a significant relationship between spiritual well-being and child behavioral disorders (P<0.01), mental health and child behavioral disorders (P<0.01), child-mother interaction and mental health (P<0.01), and spiritual well-being and mental health (P<0.01), but there was no a significant relationship between child-mother interaction and child behavioral disorders (P>0.05). Moreover, indirect paths of child-mother interaction and child behavioral disorders with a mediating role of mental health (P<0.01) and spiritual well-being and child behavioral disorders with a mediating role of mental health were significant (P<0.05).<br> <strong>Conclusion</strong>: According to the results of this study, the proposed model had a good fit, and is an important step in identifying the factors affecting the child behavioral disorders of children with hearing impairment. Hearing impairment, Mental health, Child-mother interaction, Spiritual and mental disorders 275 284 http://jrh.gmu.ac.ir/browse.php?a_code=A-10-1853-1&slc_lang=en&sid=1 Maryam Pourseyyed Mohammad samohammadif@gmail.com 1744543283 100319475328460020596 No Department of Psychology, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran. Farah Naderi naderifa2@gmail.com 1744543283 100319475328460020597 Yes Department of Psychology, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran. Parvin Ehteshamzadeh ehteshamzadehp@gmail.com 1744543283 100319475328460020598 No Department of Psychology, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran. Parviz Asgari paskarii45@gmail.com 1744543283 100319475328460020599 No Department of Psychology, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran.