en ● Psychosocial Health مقاله اصيل پژوهشي Orginal Article <div style="text-align: justify;"><span style="line-height:2;"><strong>Background</strong>: Dermatologic diseases have considerable effects on patients&rsquo; health-related quality of life (HRQoL). The assessment of diseases&rsquo; effects on patients&rsquo; lives is an important component of disease management. Although Skindex-29 is one of the most utilized measures for assessing dermatology-specific HRQoL, there is no Persian version of it in Iran. This study aimed to translate Skindex-29 into Persian and assess its psychometric properties.<br> <strong>Methods</strong>: The study was a methodological study, carried out to examine the psychometric properties and factor structure of the Persian version of Skindex-29. The translation was conducted based on Mapi guidelines. In total, 200 dermatologic patients filled in the dermatology life quality index and the Persian version of Skindex-29. Internal consistency reliability was assessed using Cronbach alpha. Convergent validity and known-group validity were evaluated. Exploratory and confirmatory factor analyses were conducted to test construct validity.<br> <strong>Results</strong>: The final translated version was comprehensible and Cronbach alpha was 0.967. Skindex-29 total score and its subscales exhibited strong correlations with the dermatology life quality index. Known-group validity was supported by the difference between the mild and severe disease groups (P<0.05). Factor analyses identified three well-fitting factors like the original version, which accounted for 69.95% of the variance of the instrument.<br> <strong>Conclusion</strong>: This study developed an adequate Persian version of Skindex-29, which can be used as a valid and reliable HRQoL instrument to study Iranian dermatologic patients.&nbsp;</span></div> Dermatologic, Health-related quality of life, Measurement, Psychometrics, Validation 279 290 http://jrh.gmu.ac.ir/browse.php?a_code=A-10-2021-1&slc_lang=en&sid=1 Soheila Aminizadeh aminizadeh@ens.uk.ac.ir 100319475328460023913 100319475328460023913 No Department of Psychology, Faculty of Literature and Humanities, Shahid Bahonar University of Kerman, Kerman, Iran. Ghasem Askarizadeh gh.askarizadeh@uk.ac.ir 100319475328460023914 100319475328460023914 Yes Department of Psychology, Faculty of Literature and Humanities, Shahid Bahonar University of Kerman, Kerman, Iran. Masoud Bagheri mbagheri@uk.ac.ir 100319475328460023915 100319475328460023915 No Department of Psychology, Faculty of Literature and Humanities, Shahid Bahonar University of Kerman, Kerman, Iran.