en ● International Health مقاله اصيل پژوهشي Orginal Article <div style="text-align: justify;"><span style="font-size:12pt"><span style="line-height:150%"><span style="font-family:Calibri,sans-serif"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><strong>Background:</strong> Physicians&rsquo; and nurses&rsquo; experience of the COVID-19 pandemic and its physical and psychological consequences can be associated with changes in biological and hormonal levels experienced as fatigue, restlessness, disruptions in one&rsquo;s mood, and sleep quality. This study examined the role of depression and death anxiety in contracting COVID-19 among healthcare staff.<br> <strong>Methods: </strong>The statistical population of this descriptive correlational research comprised nurses and nurse assistants working in Tehran (Iran) hospitals from the summer to winter of 2021. A sample of 156 was selected to fill out a demographic information form, Templer&rsquo;s death anxiety scale, and Beck&rsquo;s depression inventory. The data were analyzed in SPSS software, version 25.0 using logistic regression analysis.<br> <strong>Results:</strong> The model based on three predictors of depression (cognitive, affective, and physical components) led to a significantly better prediction compared to the fixed-effects model (P<0.001). The affective component of depression was a more powerful predictor of the risk of COVID-19 than the other two components. The model based on three predictors of death anxiety (absolute death anxiety, fear of pain and surgery, and the general factor) also led to a significantly better prediction compared to the fixed-effects model (P<0.001). All three components of death anxiety were statistically significant predictors of COVID-19 risk<br> <strong>Conclusion:</strong> Consequently, depression and death anxiety seem to predict and explain the risk of COVID-19 in healthcare staff by altering cognitive, affective, and physical conditions.&nbsp;</span></span></span></span></span></div> Anxiety, Depression, COVID-19, Fear, Nurses 347 354 http://jrh.gmu.ac.ir/browse.php?a_code=A-10-2030-1&slc_lang=en&sid=1 Fatemeh Izadi fatmoghadam@yahoo.com 0062532266 100319475328460024940 No Department of Psychology, Roudehen Branch, Islamic Azad University, Roudehen, Iran. Pegah Farokhzad dr.pegahfarokzad@gmail.com 0062532266 100319475328460024941 Yes Department of Psychology, Roudehen Branch, Islamic Azad University, Roudehen, Iran