en ● International Health مقاله اصيل پژوهشي Orginal Article <div style="text-align: justify;"><strong>Background</strong>: One of the factors affecting people&rsquo;s mental health is having repeated and confused thoughts about COVID-19. In this regard, the present study was conducted to investigate the effectiveness of cognitive-behavioral therapy on coping strategies and anxiety sensitivity of patients with COVID-19 obsession.<br> <strong>Methods</strong>: The present research method was quasi-experimental and pre-test-post-test design with a control group. The statistical population of the study included patients with COVID-19 obsession in 2021. The study sample includes 30 patients with COVID-19 obsession who were selected using the convenience sampling method and were randomly divided into two experimental groups (n=15) and control groups (n=15). The collection tool included a questionnaire on COVID-19 obsession, coping strategies, and anxiety sensitivity. The experimental group received ten 90-minute sessions of cognitive-behavioral therapy, but the control group received no intervention. Finally, the obtained data were analyzed by multivariate covariance analysis in SPSS software, version 24 (P<0.05).<br> <strong>Results</strong>: The results showed that cognitive-behavioral therapy significantly increased the problem-oriented coping strategy and decreased the emotion-oriented coping strategy, avoidance coping strategy, and anxiety sensitivity (physical, cognitive and social) in patients with COVID-19 obsession (P<0.01).<br> <strong>Conclusion</strong>: The obtained findings indicated that cognitive-behavioral therapy can significantly improve the patients with COVID-19 obsession. Considering the long-term consequences of COVID-19, psychology and counseling centers should take measures to identify and treat vulnerable groups.&nbsp;<br> <br> <span style="font-size:11pt"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:115%"><span sans-serif="" style="font-family:Calibri,"><span style="font-size:12.0pt"><span style="line-height:115%"><span style="font-family:"Times New Roman","serif""></span></span></span></span></span></span></span></span></div> Cognitive-behavioral therapy, Coping strategies, Anxiety sensitivity, COVID-19 obsession 41 50 http://jrh.gmu.ac.ir/browse.php?a_code=A-10-1922-2&slc_lang=en&sid=1 Farzin Bagheri Sheykhangafshe farzinbagheri@modares.ac.ir 100319475328460025879 100319475328460025879 Yes Department of Psychology, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran. Ali Fathi-Ashtiani fathi@bmsu.ac.ir 100319475328460025880 100319475328460025880 No Behavioral Sciences Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Vahid Savabi Niri vahid.savabi@yahoo.com 100319475328460025881 100319475328460025881 No Department of Clinical Psychology, Faculty of Humanities, Ardabil Branch, Islamic Azad University, Ardabil, Iran. Samaneh Otadi s.otadi1362@gmail.com 100319475328460025882 100319475328460025882 No Department of Clinical Psychology, Faculty of Humanities, Islamshahr Branch, Islamic Azad University, Tehran, Iran. Hamed Rezaei Golezani hamed.rezaei.g765@gmail.com 100319475328460025883 100319475328460025883 No Department of Experimental Psychology, Faculty of Humanities, Urmia Branch, Islamic Azad University, Urmia, Iran.