en ● Disease Control مقاله اصيل پژوهشي Orginal Article <div style="text-align: justify;"><span style="font-size:12pt"><span style="font-family:&quot;Times New Roman&quot;,serif"><b><span style="color:black">Background</span></b><span style="color:black">: The impact of maternal COVID-19 infection on fetal and neonatal outcomes remains incompletely understood. This study investigated the association between COVID-19 infection during pregnancy and fetal-neonatal outcomes.</span></span></span><br> <span style="font-size:12pt"><span style="font-family:&quot;Times New Roman&quot;,serif"><b><span style="color:black">Methods</span></b><span style="color:black">: In this historical cohort study, data from 349 pregnant women (86 COVID-19&ndash;infected and 263 non-infected) who delivered at Bohlol Hospital in Gonabad, Iran, between 2020 and 2022 were analyzed. Demographics, obstetric history, pregnancy complications, and fetal-neonatal outcomes were extracted from medical records. Linear, logistic, and Firth logistic regression models were used to analyze data.</span></span></span><br> <span style="font-size:12pt"><span style="font-family:&quot;Times New Roman&quot;,serif"><b><span style="color:black">Results</span></b><span style="color:black">: Women with COVID-19 had higher proportions of prior pregnancy complications, including gestational diabetes, miscarriage, and precipitous labor, and higher current gestational diabetes and preeclampsia (all p < 0.05). Infants of infected mothers had higher mean birth weight (adjusted B = 203.66, 95% CI 71.44&ndash;335.48, p = 0.003) and lower risk of low birth weight (adjusted OR = 0.28, 95% CI 0.10&ndash;0.73, p = 0.010). Although unadjusted analyses suggested higher odds of ventilation dependency and resuscitation among infants of infected mothers, these were not significant after adjustment (ventilation aOR 0.56, 95% CI 0.12&ndash;2.69, p = 0.466; resuscitation aOR 0.41, 95% CI 0.14&ndash;1.21, p = 0.105). No significant differences were found for preterm birth, early neonatal death, NICU admission, or Apgar scores.</span></span></span><br> <span style="font-size:12pt"><span style="font-family:&quot;Times New Roman&quot;,serif"><b><span style="color:black">Conclusion</span></b><span style="color:black">: Maternal COVID-19 infection was not associated with adverse effects on fetal-neonatal outcomes in this cohort. These findings provide reassurance for pregnant women and clinicians and underscore the importance of standard prenatal care and continued surveillance during future pandemics.</span></span></span></div> COVID-19, pregnancy, maternal, neonatal, outcome, Iran 11 11 http://jrh.gmu.ac.ir/browse.php?a_code=A-10-646-3&slc_lang=en&sid=1 Leila Ghorbi Lyla.ghorbi@gmail.com 100319475328460048432 100319475328460048432 No Clinical researcher, Gonabad University of Medical Sciences, Gonabad, Iran. Zahra Rastin Rastin.z@gmu.ac.ir 100319475328460048433 100319475328460048433 No Supporting of the family and the youth of population Research core, Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Azamsadat Mahmoudian azamsadat@niosha.ac.ir 100319475328460048434 100319475328460048434 No Department of Obstetrics and Gynecology, School of Medicine, Social Determinants of Health Research Center, Gonabad University of Medical Sciences, Gonabad, Iran. Fatemeh Mohammadzadeh fmhz.uni@gmail.com 0943500214 100319475328460048435 Yes Department of Epidemiology & Biostatistics, Social Development & Health Promotion Research Center, School of Health, Gonabad University of Medical Sciences, Gonabad, Iran.