Volume 15, Issue 4 (Jul & Aug-In Press 2025)
J Research Health 2025, 15(4): 8-8 |
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Ahmadi R, Vakili V, Sharifpour P. Comparison of the Efficacy of Gentamicin and Streptomycin in the Treatment of Brucellosis in Humans: A Systematic Review Study. J Research Health 2025; 15 (4) :8-8
URL: http://jrh.gmu.ac.ir/article-1-2626-en.html
URL: http://jrh.gmu.ac.ir/article-1-2626-en.html
1- Department of family medicine, school of medicine, Mashhad University of medical science، Mashhad, Iran , drrezaahmadi17@gmail.com
2- Department of family medicine, school of medicine, Mashhad University of medical science, Mashhad, Iran.
3- Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran
2- Department of family medicine, school of medicine, Mashhad University of medical science, Mashhad, Iran.
3- Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract: (368 Views)
Background: Brucellosis is the most common zoonotic infection which is transmitted to humans through direct contact with infected animals or their products (e.g. milk). Choosing an appropriate antibiotic regime that minimizes recurrence and treatment failure has always been a challenging aspect of treating brucellosis. In recent years, several studies have compared the efficacy of Streptomycin and Gentamicin in treatment of brucellosis, but it is still not completely clear which of these antibiotics is superior.
Methods: Medline and Scopus databases were searched and all English articles published from January 2006 until January 2020 that had assessed the efficacy of Streptomycin and Gentamicin in treating human brucellosis were carefully evaluated.
Results: In total, 11 studies were found that met the inclusion criteria. Of these, 2 were reviews, 2 were clinical trials and the other 7 studies were lab experiments. 4 of the studies had been performed in Iran. Number of subjects in the evaluated articles ranged from 50 to 323. Most of the studies had focused on the adult population, with only one study that had been specifically performed on children above 8 years old. In lab experiments, human brucellosis agents were almost equally sensitive to both Streptomycin and Gentamicin. In clinical trials, both antibiotics were effective in treating brucellosis.
Conclusion: Both Streptomycin and Gentamicin could safely be used in combination with Doxycycline to successfully treat brucellosis.
Methods: Medline and Scopus databases were searched and all English articles published from January 2006 until January 2020 that had assessed the efficacy of Streptomycin and Gentamicin in treating human brucellosis were carefully evaluated.
Results: In total, 11 studies were found that met the inclusion criteria. Of these, 2 were reviews, 2 were clinical trials and the other 7 studies were lab experiments. 4 of the studies had been performed in Iran. Number of subjects in the evaluated articles ranged from 50 to 323. Most of the studies had focused on the adult population, with only one study that had been specifically performed on children above 8 years old. In lab experiments, human brucellosis agents were almost equally sensitive to both Streptomycin and Gentamicin. In clinical trials, both antibiotics were effective in treating brucellosis.
Conclusion: Both Streptomycin and Gentamicin could safely be used in combination with Doxycycline to successfully treat brucellosis.
Type of Study: Review Article |
Subject:
● Disease Control
Received: 2024/09/23 | Accepted: 2025/04/5 | Published: 2025/06/20
Received: 2024/09/23 | Accepted: 2025/04/5 | Published: 2025/06/20
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