Volume 15, Issue 4 (Jul & Aug 2025)
J Research Health 2025, 15(4): 375-382 |
Back to browse issues page
Ethics code: 0
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Ahmadi R, Vakili V, Sharifpour P. Comparing the Efficacy of Gentamicin and Streptomycin on Brucellosis: A Systematic Review. J Research Health 2025; 15 (4) :375-382
URL: http://jrh.gmu.ac.ir/article-1-2626-en.html
URL: http://jrh.gmu.ac.ir/article-1-2626-en.html
1- Department of Family Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
2- Department of Family Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. ,Vidavakili@gmail.com
3- Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
2- Department of Family Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. ,
3- Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
Abstract: (1666 Views)
Background: Brucellosis is the most common zoonotic infection, which is transmitted to humans through direct contact with infected animals or their products (e.g. milk). Choosing an appropriate antibiotic regimen that minimizes recurrence and treatment failure has always been a challenging aspect of treating brucellosis. In recent years, several studies have compared the efficacy of streptomycin and gentamicin in treating brucellosis, but it is still not completely clear which antibiotic is superior.
Methods: Medline and Scopus databases were searched. All English articles published from January 2006 until January 2020 that assessed the efficacy of streptomycin and gentamicin in treating human brucellosis were carefully evaluated.
Results: In total, 11 studies met the inclusion criteria. Of these, 2 were reviews, 2 were clinical trials, and the other 7 studies were lab experiments. Four studies had been performed in Iran. The number of subjects in the evaluated articles ranged from 50 to 323. Most studies focused on the adult population, with only one specifically focusing on children above 8 years old. Human brucellosis agents were almost equally sensitive to streptomycin and gentamicin in lab experiments. In clinical trials, both antibiotics were effective in treating brucellosis.
Conclusion: Streptomycin and gentamicin could safely be used with doxycycline to treat brucellosis successfully.
Methods: Medline and Scopus databases were searched. All English articles published from January 2006 until January 2020 that assessed the efficacy of streptomycin and gentamicin in treating human brucellosis were carefully evaluated.
Results: In total, 11 studies met the inclusion criteria. Of these, 2 were reviews, 2 were clinical trials, and the other 7 studies were lab experiments. Four studies had been performed in Iran. The number of subjects in the evaluated articles ranged from 50 to 323. Most studies focused on the adult population, with only one specifically focusing on children above 8 years old. Human brucellosis agents were almost equally sensitive to streptomycin and gentamicin in lab experiments. In clinical trials, both antibiotics were effective in treating brucellosis.
Conclusion: Streptomycin and gentamicin could safely be used with doxycycline to treat brucellosis successfully.
Type of Study: Review Article |
Subject:
● Disease Control
Received: 2024/09/23 | Accepted: 2025/04/5 | Published: 2025/07/1
Received: 2024/09/23 | Accepted: 2025/04/5 | Published: 2025/07/1
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
This is an open access article distributed under the terms of the Creative Commons Attribution License (CC-By-NC), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Contact Information
