en مقاله اصيل پژوهشي Orginal Article <strong>Background</strong>: Today, information resources play a paramount importance role in providing information and public awareness. COVID-19 is a highly contagious disease and general precautions and identifying the factors influencing the self-care behaviors play an important role in the prevention of the disease. This study aimed to assess the relationship between trust in information resources and self-care behaviors in the prevention of COVID-19 on faculty members, staff, or students of Gonabad University of Medical Sciences.<br> <strong>Methods</strong>: This was an analytical cross-sectional study, conducted on 192 faculty members, staff, or students of Gonabad University of Medical Sciences between May and April 2020. The sampling method was census. We used a valid and reliable questionnaire to assess our goals. Data on demographic variables, information resources trust and self-care behaviors to them were collected using online self-administered questionnaires. Data were analyzed using SPSS software v. 22 and Chi-square test and Pearson correlation coefficient.<br> <strong>Results</strong>: In this study, 60.2% of the subjects were male. The Mean&plusmn;SD age was 24.18&plusmn;7.97 years (ranged: 18-59). The highest levels of trust in the information resources about COVID-19 were related to articles (37.8%) and faculty information (22.2%), and the lowest ones were related to national media (27.3%) and satellite channels (25.5%). The quality of self-care behavior in females was significantly higher than males (P=0.018). There was no significant relationship between the level of trust in any of the information resources and the quality of self-care behaviors in the prevention of COVID-19 (P>0.05).<br> <strong>Conclusion</strong>: According to the results of this study, there was no significant relationship between the level of trust in information resources and the quality of self-care behaviors to prevent COVID-19 and further investigations are needed to find possible associated factors. Social Media, Trust, Self-Care, Information Services, SARS-CoV-2 49 56 http://jrh.gmu.ac.ir/browse.php?a_code=A-10-1901-2&slc_lang=en&sid=1 Maliheh Ziaee malihehziaee@gmail.com 0919342876 100319475328460022700 No Department of Community Medicine, School of Medicine, Social Determinants of Health Research Center, Gonabad University of Medical Sciences, Gonabad, Iran. Adoljavad Khajavi abjkhajavi@gmail.com 09151779420 100319475328460022701 No Department of Social Medicine, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran. Alireza Najafzadeh alirezanj1377@yahoo.com 09944328360 100319475328460022702 No Student Research Committee, Gonabad University of Medical Sciences, Gonabad, Iran. Mitra Tavakolizadeh tavakolizadeh.m@gmu.ac.ir 0919920128 100319475328460022703 Yes Clinical Research Development Unit, Bohlool Hospital, Gonabad University of Medical Sciences, Gonabad, Iran. Sepideh Karkon Shayan Sepidehshayan76@gmail.com 09149238077 100319475328460022704 No Student Research Committee, Gonabad University of Medical Sciences, Gonabad, Iran.