Volume 15, Issue 5 (Sep & Oct- In Press 2025)
J Research Health 2025, 15(5): 8-8 |
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Chukwu O, Anakwue R, Iyare C, Alagbonsi A. A Decade of Managing Organophosphate Poisoning: Systematic Review. J Research Health 2025; 15 (5) :8-8
URL: http://jrh.gmu.ac.ir/article-1-2732-en.html
URL: http://jrh.gmu.ac.ir/article-1-2732-en.html
1- Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, David Umahi Federal University of Health Sciences, Ebonyi State, Nigeria. , chukwuoo46@gmail.com
2- Department of Pharmacology and Therapeutics, University of Nigeria, Enugu Campus, Nigeria
3- Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, David Umahi Federal University of Health Sciences, Ebonyi State, Nigeria
4- Department of Physiology, School of Medicine and Pharmacy, College of Medicine and Health Sciences, University of Rwanda, Huye, Rwanda
2- Department of Pharmacology and Therapeutics, University of Nigeria, Enugu Campus, Nigeria
3- Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, David Umahi Federal University of Health Sciences, Ebonyi State, Nigeria
4- Department of Physiology, School of Medicine and Pharmacy, College of Medicine and Health Sciences, University of Rwanda, Huye, Rwanda
Abstract: (241 Views)
Background: Organophosphate (OP) poisoning remains a significant public health concern. This systematic review aimed to assess current state of knowledge on management of OP poisoning.
Method: A comprehensive search of PubMed, Scopus, Web of Science, and Google Scholar was conducted using relevant keywords such as ‘organophosphate poisoning’, ‘pesticide exposure’, and ‘agricultural workers. Search was restricted to studies published between 2014 and 2024. Filters were applied to include only articles in English, focusing on human and animal studies, clinical trials, and observational research. Studies were included if they examined OP poisoning, particularly in rural populations or agricultural workers, and excluded if not written in English, non-peer-reviewed, or lacking relevant biomarkers or outcomes. Data from each study were extracted using a standardized form and analyzed thematically, focusing on key outcomes like exposure risks, treatment methods, and poisoning-related mortality.
Results: Of the 152 studies initially identified, 25 were included in the final analysis. Majority of included studies focused on clinical management of OP poisoning, including use of antidotes and supportive care. However, there is a paucity of research on long-term health outcomes and effectiveness of preventive interventions in rural settings. Key findings from the included studies highlight the importance of early diagnosis and prompt treatment.
Conclusion: While the review did not find significant treatment advances, it emphasized continued relevance of promoting safe pesticide use, education, and awareness in preventing OP poisoning in agricultural communities. Rural populations, who are disproportionately affected due to higher exposure to agricultural chemicals and limited access to healthcare and education, require targeted public health interventions. Future studies should focus on more effective prevention strategies and therapeutic interventions to address unique vulnerabilities of rural communities, including community-based interventions and digital health technologies.
Method: A comprehensive search of PubMed, Scopus, Web of Science, and Google Scholar was conducted using relevant keywords such as ‘organophosphate poisoning’, ‘pesticide exposure’, and ‘agricultural workers. Search was restricted to studies published between 2014 and 2024. Filters were applied to include only articles in English, focusing on human and animal studies, clinical trials, and observational research. Studies were included if they examined OP poisoning, particularly in rural populations or agricultural workers, and excluded if not written in English, non-peer-reviewed, or lacking relevant biomarkers or outcomes. Data from each study were extracted using a standardized form and analyzed thematically, focusing on key outcomes like exposure risks, treatment methods, and poisoning-related mortality.
Results: Of the 152 studies initially identified, 25 were included in the final analysis. Majority of included studies focused on clinical management of OP poisoning, including use of antidotes and supportive care. However, there is a paucity of research on long-term health outcomes and effectiveness of preventive interventions in rural settings. Key findings from the included studies highlight the importance of early diagnosis and prompt treatment.
Conclusion: While the review did not find significant treatment advances, it emphasized continued relevance of promoting safe pesticide use, education, and awareness in preventing OP poisoning in agricultural communities. Rural populations, who are disproportionately affected due to higher exposure to agricultural chemicals and limited access to healthcare and education, require targeted public health interventions. Future studies should focus on more effective prevention strategies and therapeutic interventions to address unique vulnerabilities of rural communities, including community-based interventions and digital health technologies.
Keywords: Organophosphate Poisoning, Pesticide Exposure, Agricultural workers, Rural populations, Farm
Type of Study: Review Article |
Subject:
● International Health
Received: 2025/01/25 | Accepted: 2025/04/5 | Published: 2025/08/5
Received: 2025/01/25 | Accepted: 2025/04/5 | Published: 2025/08/5
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