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Kianmehr M, Rafraf M, Molani-Gol R, Kianmehr M, Hosseini A. Association of Nonalcoholic Fatty Liver Disease Severity With General and Central Obesity, and Physical Activity in Adults. J Research Health 2026; 16 (1) :95-102
URL: http://jrh.gmu.ac.ir/article-1-2798-en.html

A Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide. Many risk factors are associated with NAFLD, such as a sedentary lifestyle and obesity. This study aimed to investigate the association between disease severity, obesity, and physical activity levels in adults with NAFLD. A total of 280 adults with NAFLD were selected by a gastroenterologist using convenience sampling. NAFLD severity was assessed by ultrasound, and participants’ physical activity was evaluated using the short version of the International Physical Activity Questionnaire. Regarding NAFLD grade, 24.6% were grade 1, 63.2% were grade 2, and 12.2% were grade 3. The mean body mass index and waist circumference of the study participants were 29.19±4.14 kg/m2 and 100.99±9.24 cm, respectively. A significant positive relationship was observed between the degree of general obesity and NAFLD severity. As obesity increased, NAFLD severity also increased (P=0.045). A significant inverse relationship was observed between the level of physical activity and NAFLD grade (P=0.002). Considering the association between NAFLD grade, obesity, and physical activity, it is recommended that health and educational programs be developed to promote a healthy lifestyle and physical activity to reduce the prevalence of obesity and NAFLD.