Hypertension is epidemic disease which post-exercise hypotension (PEH) is useful strategies for hypertension. The aim of present study was to investigate the effects of resistance exercise leading to failure (REF) and resistance exercise not to failure (NREF) on PEH phenomenon in trained men. Eight trained men (age: 22.12±1.81 yr; height: 179±3.44 cm; weight: 73.82±4.29 kg; BMI: 23.01±0.84 Kg/m2 body fat 12.91±1.15%) by using the counter-balanced crossover design and in randomized order performed REF and NREF protocols by leg press machine and one session rested as control session. participants performed REF in 5 sets with 10 repetitions and NREF in 10 sets with 5 repetitions with the same load (10RM) and one min rest intervals between sets. Blood pressure was measured before and for 60 min post-resistance exercise protocols and control test. Based on the results of provided by repeated measures analysis of variance, blood pressure did not change significantly during the control test. But a significant decrease in the systolic, diastolic and mean blood pressure was observed after REF and NREF protocols when compared with the baseline values. However, duration and magnitude of PEH after REF was significantly higher in comparison of NREF protocol. The present study indicated that PEH was influenced by failure; because duration and magnitude of PEH were provided by REF was higher in comparison of NREF protocol. Therefore, REF can be more effective strategy to prevent prevalence of hypertension.