Happiness is one of the most important human psychological needs that plays a key role in the formation of a person's character and mental health. This quasi-experimental study aimed to determine the effect of happiness training in reducing depression and anxiety and improving quality of life among hemodialysis patients. The participants consisted of 30 female dialysis patients that referred to hemodialysis ward in Zahedan city. The participants were placed in two groups, experimental and control, each included 15 members. Afterwards, the Fordyce happiness training was implemented on the experimental group in 8 sessions (a 90-minute session per week). Pretest and posttest were conducted on both groups. In the current study, for gathering data in the pretest and posttest, the Beck Depression Inventory, Katel Anxiety Questionnaire, and 36-Item Short Form (SF-36) Health Survey were employed. The results of the data analysis showed significant differences between the mean scores of the hemodialysis patients placed in the experimental and control groups on depression, anxiety, and quality of life. Accordingly, it can be concluded that the happiness training was effective in reducing the patients' depression and anxiety and enhancing their quality of life.