AIDS is a medical health phenomenon who’s social, cultural and economic dimensions are very widespread. Little information about this disease is emerging because of its recent development. Regarding the youth and adolescent, these are the groups most at risk of infection to AIDS, and the only means of controlling the disease is education and increasing knowledge. So, this study is aimed at comparing the effect of two methods of film display and educational booklets on the knowledge and attitude of girl students towards AIDS. This study was a semi-experimental study, 600 girl students from among girl students of Zahedan city were chosen using cluster sampling in 2009. They were divided into 3 groups (showing movies, educational booklet and control). The data were collected by a structured questionnaire in two stages, before and after the intervention. The obtained data were analyzed by SPSS software V. 15 at significant level of 0. 05. In order to compare the level of knowledge before and after the intervention, Chi-square and Exact Fisher tests were employed. There was a significant difference in level of knowledge between the groups before and after intervention (p=0. 00), attitude of showing movies group was more positive than that of the other two groups (p=0. 001). In conclusion, for improving the knowledge about AIDS, showing movie method is more effective than the booklet method in girl students.