The aim of this study was the effectiveness of behavioral couple’s therapy to reduce domestic violence in women substance abusers. The design of this study was experimental with pre-test, pos-ttest and fallow up with control group. The study included all couples that had referred to Cessation clinic for substance abuse in Ahvaz city that among them 20 couples were selected and randomly divided into two groups as experiment and control. Research instrument include Scale of Violence against Women and Structured interview by clinical centers psychiatrist. In order to analyze the resulted data, univariate analysis of covariance (ANCOVA) and multivariate analysis of covariance (MANCOVA) analyzing method is used along with SPSS16. The results showed that there was a significant difference in domestic violence between two groups (P<0/001). In addition, these results have been consistent in follow up period (P<0/001). The acquired results revealed that behavioral couple’s therapy was effect in reducing domestic violence.