The aim of this study was to investigate the multiple relationships between anxiety sensitivity, social support, and perception of pain with the  life expectancy. Research was of correlational type. Population was consisted of all older adult in Isfahan (males and females) in the spring of 2016. 250 individuals were selected by convenience sampling method from different places. In order to measure the variables, Hope based on Islamic Sources, Perceived Social Support, Anxiety Sensitivity and the Perception of Pain questionnaires were used. Data analysis was conducted by Pearson correlation and simultaneous multiple regression analysis. The Results indicated that there exists a significant positive relationship between anxiety sensitivity, social support and the perception of pain with life expectancy (p<0.01). This result implies that social protection enhancement, not only increases hope but also affects the fear of one’s anxiety observed by others, the perception of pain and the fear of lack of cognitive control.